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Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia
InChiKey: JXSVVZKPEDIRTN-DHZHZOJOSA-N
Tofogliflozin improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus
InChi: InChI=1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10
Solubility: DMSO : ≥ 37 mg/mL (133
A 412997 dihydrochloride Size:Contact [email protected] for quotation Exploiting an Asp-Glu "switch" inA 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7. 9 and 12. 1 nM for human and rat D4 receptors, respectively . Dopamine D4 receptor is a G protein coupled receptor and is activated by dopamine. It plays an important role in cognition, Parkinsons disease, addictive behaviors and so on. A 412997 dihydrochloride is a selective dopamine D4 receptor agonist. In calcium flux functional assays, A 412997 activated