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J Clin Virol
CPI-169 was subcutaneously (SC) dosed to mice bearing KARPAS-422 subcutaneous xenografts at 200 mg/kg twice per day
a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
Formula: C18H22N2O
Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM
(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 J Clin VirolMutations, CAS No. 103404 90 6, in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, such as leukemia and glioma, and result in overproduction of the (R) enantiomer of 2 hydroxyglutarate [(R) 2 HG]. Elucidation of the role of IDH mutations and (R) 2 HG in leukemogenesis has been hampered by a lack of appropriate cell based models. It has been recently reported that a canonical IDH1 mutant, IDH1