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21(5):323-331
is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation
Formula: C12H14N2O2
Am J Physiol Endocrinol Metab
1'-biphenyl]-4-yl)methyl)benzenesulfonamide
Torin 1 - CAS# 1222998-36-8 Catalog No.:M6633-2 21(5):323-331Torin 1, CAS No. 1222998 36 8, is a potent and selective mTOR inhibitor. The apoptosis inducing mTOR inhibitor Torin 1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin 1 also affected the expression of markers for cell proliferation, angio lympho genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly,