CEP 1347 ITC 7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1

7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1

USP7-IN-8 shows no activity against USP47 and USP5

Solubility: DMSO : 20 mg/mL (61

PubMed PMID: 25377080

CAS Number: 2856-75-9

CEP 1347 ITC 7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1CEP 1347, also called KT 7515, is an inhibitor of the c Jun N terminal kinase (JNK) signaling pathway, with an IC50 value for JNK1 activation of 20 2 nM in rat embryonic motoneurons . The JNK pathway, also known as the stress activated protein kinase (SAPK) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. JNK activation by phosphorylation is important for neuronal cell death