Tankyrase Inhibitors (TNKS) 22 halin 2R)-2-[(cyclopropylmethyl)amino]cyclopropyl]phenyl}-1-methyl-1H-pyrazole-4-carboxamide hydrochloride

2R)-2-[(cyclopropylmethyl)amino]cyclopropyl]phenyl}-1-methyl-1H-pyrazole-4-carboxamide hydrochloride

with a Kb of 1 nM and a Ki of 4 nM at human MCH1

Formula: C17H16N4O

In PC-3 prostate cancer cells

99 mM) H2O : < 0

Tankyrase Inhibitors (TNKS) 22 halin 2R)-2-[(cyclopropylmethyl)amino]cyclopropyl]phenyl}-1-methyl-1H-pyrazole-4-carboxamide hydrochlorideTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis