Z-DQMD-FMK 17517 CC1C2NC3C=CC=CC=3C=2C(C)=C2C=NC=CC=12

CC1C2NC3C=CC=CC=3C=2C(C)=C2C=NC=CC=12

InChi: InChI=1S/CH4N2O/c2-1(3)4/h(H4

Bailey A W

BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions

2 μM for A

Z-DQMD-FMK 17517 CC1C2NC3C=CC=CC=3C=2C(C)=C2C=NC=CC=12Inhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and