Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 CAS Number: 1093978-89-2

CAS Number: 1093978-89-2

quickly equilibrating with the central nervous system

2Na/c8-7(9)5-1-3-6(4-2-5)13-14(10

leaving the muscle origin and insertion points intact

emodin limits the effect of glucocorticoids and may therefore ameliorate diabetes and insulin resistance

Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 CAS Number: 1093978-89-2Ruxolitinib sulfate is the first potent, selective JAK1 2 inhibitor to enter the clinic with IC50s of 3. 3 nM 2. 8 nM, and has > 130 fold selectivity for JAK1 2 versus JAK3. Ruxolitinib potently and selectively inhibits JAK2V617F mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba F3 cells. Ruxolitinib demonstrates remarkable