AN-2690 Size:Solid 2 mg PubMed Central PMCID: PMC4315073

PubMed Central PMCID: PMC4315073

and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics

Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy

Pimecrolimus is found to be as effective as cyclosporine A following oral ingestion and slightly superior after subcutaneous administration in mice

which are critical components of the bacterial cell wall

AN-2690 Size:Solid 2 mg PubMed Central PMCID: PMC4315073Tavaborole, also known as AN 2690 (trade name Kerydin) is a topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed. Tavaborole began its Phase 3 trials in December 2010 and was approved in July 2014. Tavaborole inhibits an essential fungal enzyme, Leucyl tRNA synthetase, or LeuRS, required for protein synthesis. The inhibition of protein synthesis leads to termination of cell growth and cell