ZJ 43 60075 3 hours) has anti-inflammatory activity

3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells

CAS Number: 31521-83-2

GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells

2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl)-2

(2003) Blood

ZJ 43 60075 3 hours) has anti-inflammatory activityIC50: 2. 4 nM ZJ 43 is a N acetylaspartylglutamate (NAAG) peptidase inhibitor. The peptide neurotransmitter N acetylaspartylglutamate (NAAG) is reported to act as an agonist at group II metabotropic glutamate receptors. NAAG is inactivated by extracellular peptidase activity leading to yielding glutamate and N acetylaspartate. In vitro: As a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III) with Kivalues of 0. 8 and 23 nM