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IDO5L and IDO-IN-2 with CAS#914471-09-3
It binds to the Rad6B catalytic site
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9
Solubility: DMSO up to 100mM
Right now FG-4592 is in phase III clinical trials to treat anemia
Verteporfin (Visudyne) - YAP Inhibitor. CAS# 129497-78-5 045 IDO5L and IDO-IN-2 with CAS#914471-09-3Verteporfin (Visudyne), CAS No. 129497 78 5, is a potent and selective YAP inhibitor, disrupts YAP TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM. It inhibits growth and proliferation of retinoblastoma cells. It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+). In vivo it can suppress YAP induced liver overgrowth in mice. Product information CAS Number: