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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
CAS Number: 1450824-22-2
): Indication: For the treatment of primary biliary cholangitis [Internet]
Chemical Name: 2-Pyridinamine
LY2784544 significantly inhibits STAT5 phosphorylation in JAK2-V617F Ba/F3 xenografts with a Threshold Effective Dose 50 (TED50) of 12
MGL-3196 - CAS# 920509-32-6 PTO-253 Inhibition of SIRT1 catalytic activityMGL 3196, CAS No. 920509 32 6, also known as Resmetirom, is a potent and highly selective thyroid hormone receptor agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor (THR ) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor (THR ). Product information CAS Number:
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