Pyrimidine-indole hybrid Catalog No.:M34537-C 26(2):300-306

26(2):300-306

Chemical Name: 2-(phenylamino)benzoic acid

for 14 days) exhibits dose-dependent inhibition on HT-29 tumor growth in nude mice

MDA-MB-231 and BT-549 cells) treatment substantially reduces the LIF activation of STAT3

9-fold selectivity toward JAK1 vs

Pyrimidine-indole hybrid Catalog No.:M34537-C 26(2):300-306Pyrimidine indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of tubulin. Pyrimidine indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule