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24)/t17-/m0/s1
by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα
InChiKey: BOZRFEQDOFSZBV-DHIUTWEWSA-N
an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity
6-tetrahydropyrimidine
EL-102 islignan 24)/t17-/m0/s1EL102 is a inhibitor of HIF1 , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1IC 5020 40 nM. in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2 M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from