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P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist
The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys
but its efficacy declines as the disease progresses
Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells
Epub 2015 Jul 6
CY-09 G11-azide P-Glycoprotein inhibitor and potent dopamineCY 09 is a selective and direct NLRP3 inhibitor. CY 09 directly binds to the ATP binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. Product information CAS Number: 1073612 91 5 Molecular Weight: 423. 43 Formula: C19H12F3NO3S2 Chemical Name: 4 {[(5Z) 4 oxo 2 sulfanylidene 3 {[3 (trifluoromethyl)phenyl]methyl} 1,3 thiazolidin 5 ylidene]methyl}benzoic acid
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