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AG-490 potently inhibits IL-2-mediated human T cell growth with an IC50 of 25 μM by blocking the activities of JAK3 and STAT5a/b
InChi: InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6
serves as a powerful anti-glioma compound
GS-441524-intermediate
Formula: C16H15N3O5
Lactacystin obalamin AG-490 potently inhibits IL-2-mediated humanLactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4. 8 M for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces neurite outgrowth. Product information CAS Number: 133343 34 7 Molecular Weight: 376. 43 Formula: C15H24N2O7S Chemical Name: 2 acetamido 3 [3 hydroxy 2 (1 hydroxy 2 methylpropyl) 4 methyl 5
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