GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 la-Ala-Asn-PAB-PNP Smiles: CC1=NOC2[C@H](CC(N)=O)N=C(C3=CC=CC=C3C=21)C1C=CC(Cl)=CC=1

Smiles: CC1=NOC2[C@H](CC(N)=O)N=C(C3=CC=CC=C3C=21)C1C=CC(Cl)=CC=1

Smiles: CC1=NN(C)C2OC(N)=C(C#N)C(C1=2)C1C=CC(=CC=1)C(F)(F)F

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice

BAY 87-2243 was used at 0

Formula: C22H23ClFN5O3

GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 la-Ala-Asn-PAB-PNP Smiles: CC1=NOC2[C@H](CC(N)=O)N=C(C3=CC=CC=C3C=21)C1C=CC(Cl)=CC=1GNF7156, CAS No. 2041071 54 7, is a highly potent and selective small molecule that promotes pancreatic cell proliferation in rodent EC50 ~2. 2 Mand human primary islets (EC50 ~0. 76 M). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156 treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces cell proliferation, increases cell mass