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The expression of pFAK (Tyr397) is statistically significantly inhibited by Defactinib in a dose-dependent manner in all cell lines
and show the synergistic anti-proliferative effects in combination with ALK inhibitors in ALKpos ALCL cell lines
gov/books/NBK548824/ PubMed PMID: 31644131
Oncol Lett
Formulation is 10% N-methylpyrrilidone
Indirubin 0156 The expression of pFAK (Tyr397)Indirubin is a potent and selective CDK inhibitor. Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin has been used to treat the symptoms of leukemia. Further biological explorations revealed the ability of indirubin to bind cyclin dependent kinases and 6 bromoindirubin, extracted from mollusks, to bind glycogen synthase kinase 3. Studies have
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