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(2014) AACR San Diego
Smiles: COC1C(=CC(=CC=1OC)C1=CC(=CN=C1N)C1=CC(O)=CC=C1)OC
arenaviruses
InChi: InChI=1S/C25H36O5/c1-7-13(2)22(28)30-21-14(3)10-24-11-16(9-17(12-26)20(27)25(21
NLG919 was used at 10 µM final concentration in various in vitro assays
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 (2014) AACR San DiegoBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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