PF-04217903 Size:2mg solid 5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide

5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide

CAS Number: 2079056-43-0

Synthesis and Biological Evaluation of HighlySelective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

5-a]pyrimidin-3-yl)quinoline

InChi: InChI=1S/C23H16F3N3O6/c1-27-17-7-5-11(9-18(17)35-22(27)34)28-10-14(20(31)32)19(30)29(21(28)33)16-8-6-12-13(16)3-2-4-15(12)23(24

PF-04217903 Size:2mg solid 5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamidePF 04217903 is a MET tyrosine kinase inhibitor, is also a n orally bioavailabe, small molecule tyrosine kinase inhibitor of the proto oncogene c Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c Met inhibitor PF 04217903 selectively binds to and inhibits c Met, disrupting the c Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction