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Formula: C17H35N4O14P3
ErSO is effective against both the breast cancer cell lines expressing wild-type ERα and the ERαY537S and ERαD538G mutations such as human breast cancer cell lines TYS and TDG
Smiles: CCOC1=CC(N)=C(Cl)C=C1C(=O)NCC1CN(CC2=CC=C(F)C=C2)CCO1
1 nM in human and monkey blood
Formula: C30H34N4O2
Q-VD(OMe)-OPh 5EF hydrochloride Formula: C17H35N4O14P3Q VD OPh (quinolyl valyl O methylaspartyl [ 2,6 difluorophenoxy] methyl ketone) is a broad spectrum caspase inhibitor, provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD fmk and Boc D fmk. Q VD OPh is also equally effective in preventing apoptosis mediated by
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