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A novel small-molecule inhibitor of NF-kappaB signaling
the biologically active form of MLN9708
Arrendale RF
de Vos-Geelen J
InChiKey: ZPLBXOVTSNRBFB-UHFFFAOYSA-N
SMI-4a - CAS# 438190-29-5 0256 A novel small-molecule inhibitor ofSMI 4a, CAS No. 438190 29 5, is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T cell lymphoblastic leukemia lymphoma. SMI 4a was found to induce phosphorylation of extracellular signal related kinase1 2 (ERK1 2), and the combination of SMI 4a and a mitogen activated protein kinase kinase 1 2 (MEK1 2) inhibitor was highly synergistic in killing pre T LBL cells. SMI 4a may be developed as a therapeutic
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