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Chemical Name: (E)-N-benzyl-2-cyano-3-(3
thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death
115(3):631-6
CAS Number: 1362154-70-8
Chemical Name: N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
CB-839 H 298 Chemical Name: (E)-N-benzyl-2-cyano-3-(3Telaglenastat, also known as CB 839, an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Telaglenastat selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the
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