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is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM
It has been shown to promote goblet cell differentiation in mouse intestine
selective and cell-permeable mTOR activator
GDC-0349 demonstrates pathway modulation and dose-dependent efficacy in mouse xenograft cancer models
PubMed PMID: 22975763
GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 is a novel potent andGNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53
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