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Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages
and inhibits the estrogen response element-containing vitellogenin promoter expression
171(15):3716-27
Smiles: CO/N=C(/C1=CSC(N)=N1)\C(=O)N[C@H]1[C@H]2SCC=C(C(O)=O)N2C1=O
AL082D06 binds competitively with steroids
Thioperamide n disodium Semapimod tetrahydrochloride inhibits p38 MAPKThioperamide (MR 12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4. 3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM. Product information CAS Number: 106243 16 7 Molecular Weight: 292. 44 Formula: C15H24N4S Chemical Name: N cyclohexyl 4 (1H imidazol 5 yl)piperidine 1 carbothioamide Smiles: S=C(NC1CCCCC1)N1CCC(CC1)C1=CN=CN1 InChiKey:
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