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Nicotinamide N-oxide
1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration
Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1
and has significant anti-inflammatory and analgesic effects
GDC-0449 was used at 5-10 µM concentration in the cellular assays
Acolbifene Size:Contact [email protected] for quotation Nicotinamide N-oxideAcolbifene (EM 652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM 652) inhibits estradiol (E2) induced transcriptional activity of ER (IC50 = 2 nM) and ER (IC50 = 0. 4 nM). Acolbifene (EM 652) possesses potent and pure anticarcinogenic properties. Product information CAS Number: 182167 02 8 Molecular Weight: 457. 56 Formula: C29H31NO4 Chemical Name: (2S) 3 (4
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