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Tolliver SC
CAS Number: 1243259-19-9
and the induction of death in tumor cells expressing c-Met
regulates transcription of MDR (increase
) shows significant antitumor effect in the KMS11-bearing mice model
SCH772984 cin Tolliver SCSCH772984 is an potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non BRAF mutant
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