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IWR-1 exerts its effect via interaction with Axin
In HeLa cells
and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2)
GJ072 shows activity comparable to stop codons (TGA
Miyamoto T
PF-00562271 EG5-Tos IWR-1 exerts its effect viaPF 562271, also known as PF 562, 271 and PF 271, is an orally bioavailable small molecule and ATP competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF 562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. Product information CAS Number: 717907 75 0 Molecular Weight: 507. 49