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Smiles: C[C@]12CCC3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@@]2(O)CC#N
Pyridostatin
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
1 nM in a BT20 cell assay
is a potent
Rosuvastatin Calcium 60107 Smiles: C[C@]12CCC3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@@]2(O)CC#NRosuvastatin Calcium (Rosuvastatin hemicalcium) is a competitive HMG CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks human ether a go go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock
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