N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 17575 ) as a single agent

) as a single agent (top panel) or in combination with radiation (bottom panel) results in an increase in fluorescence intensity in the Calu-6 tumors

with inhibition of >90% when at a 1 mg/kg concentration

a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours

Z-VRPR-FMK (TFA) (VRPR)

4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]-2

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 17575 ) as a single agentN (m PEG4) N' (4 Hydroxycyclohexyl 1 amido PEG4) Cy5 is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 2107273 72 1 Molecular Weight: 926. 62 Formula: C51H76ClN3O10 Chemical Name: 2 [(1E,3E) 5 [(2E) 1 {14 [(4 hydroxycyclohexyl)carbamoyl] 3,6,9,12 tetraoxatetradecan 1 yl} 3,3 dimethyl 2,3 dihydro 1H indol 2 ylidene]penta 1,3 dien 1 yl] 3,3 dimethyl 1 (2,5,8,11 tetraoxatridecan 13 yl) 3H indol 1