HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 60293 (2002) Blood

(2002) Blood

Smiles: CC1C=C(C)C(=CC=1)N(/N=C/C1C=C(C=CC=1)OC)C(=O)C(F)(F)F

Smiles: CC(C)NC[C@H](C1=CC=C(Cl)C=C1)C(=O)N1CCN(CC1)C1=NC=NC2[C@H](O)C[C@@H](C)C=21

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

PubMed PMID: 29351391

HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 60293 (2002) BloodHG 10 102 01, CAS No. 1351758 81 0, is a brain penetrant, potent and selective inhibitor of wild type LRRK2 and the G2019S mutant (IC50 for LRRK2 wild type ~20. 3 nM and LRRK2 [G2019S] ~3. 2 nM). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild type LRRK2 and G2019S mutant at a concentration of 0. 10. 3 M in cells. HG 10 102 01 is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse