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MRTX1257 is shown to be highly selective for the targeted Cys12 of KRAS G12C versus other surface-exposed cysteine residues in NCI-H358 cells
Smiles: OC1=CC=C(C=C1[C@]12C[C@@H]3C[C@@H](C1)C[C@H](C2)C3)C1=CC2C=CC(=CC=2C=C1)C(O)=O
Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids
with MIC90s between ≤0
RP13057 Hydrochloride
Fenobam Catalog No.:M20651-C MRTX1257 is shown to beFenobam is a selective, orally active, and brain penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity. Product information CAS Number: 57653 26 6 Molecular Weight: 266. 68 Formula: C11H11ClN4O2 Chemical Name: 1