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and both analgesic and antiinflammatory effects in animal studies comparable to naproxen
the ADC payload will only be released in the cell
PubMed PMID: 21439936
PubMed Central PMCID: PMC4359246
InChiKey: SSXYXSMMVMVYEV-UHFFFAOYSA-N
PF-4136309 - CAS# 1341224-83-6 273 and both analgesic and antiinflammatoryPF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2
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