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The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex
is a competitive receptor antagonist of the OX1 and OX2 orexin receptors
Chemical Name: N-[7-cyano-6-(4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy)-1
2015 Jan 28
CAS Number: 2041073-22-5
Letrozole - CAS# 112809-51-5 Size:Solid 10 mg The ligand folds into itselfLetrozole, also known as CGS 20267, is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen dependent breast cancer cells. Aromatase, a cytochrome P 450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary,