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534(7609):647-51
consistent with drug attenuating neurodegeneration in the SNpc
transformation
At low concentrations
the KP-MRT-YM (YM) cell line is resistant to Palbociclib (IC50>10 µM)
AST-1306 (TsOH) Size:Solid 2 mg 534(7609):647-51Allitinib, also known as AST1306 and ALS 1306, is a potent, selective, irreversible ErbB2 and EGFR inhibitor. AST 1306 inhibits the enzymatic activities of wild type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell free and cell based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and
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