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AZD-9291 demonstrates improved rat PK
ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation
Formula: C20H22N4O2
Treatment with RS-1 promoted significant antitumor responses in a mouse model
also known as AMG-706
AT-406 nbolone acetate AZD-9291 demonstrates improved rat PKDeBio 1143, also known as AT 406, ARRY 334543and SM 406, is an orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. AT 406 selectively inhibits the biological activity of IAP proteins, including X chromosome linked IAP (XIAP), the cellular IAPs 1 (c IAP1) and 2 (c IAP2) and melanoma inhibitor of apoptosis protein (ML IAP). This may restore and promote
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