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Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine
and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics
Formula: C26H20F3NaO3
Burdelya L
Ter Burg J
XL388 - CAS# 1251156-08-7 Catalog No.:M9702-10 Imidazoline receptors associated with noradrenergicXL388 is a Novel Class of Highly Potent, Selective, ATP Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p p70S6K, pS6, and p 4E BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with
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