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selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9
233(1):124-140
Curr Pharm Des
Pellock JM
InChi: InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2
SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 selective and cell permeable ProteinSBI 0206965, CAS No. 1884220 36 3, is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI 0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1 mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI 0206965 greatly synergized with mechanistic target
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