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20-13-21(29(31
and has antitumor activity in vitro
Smiles: COC1=CC=C(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)C2=CC(OC)=C(OC)C(=C2)OC)C2=CC(=CC=C2)OCC(=O)NCCNC(=O)COC2=CC(=CC=C2)[C@@H](CCC2=CC(OC)=C(C=C2)OC)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)C2C=C(OC)C(OC)=C(C=2)OC)C=C1OC
also known as cGAMP
Anticancer Drugs
TIC10 ehyde 20-13-21(29(31ONC 201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53 independent manner and crosses the blood brain barrier. TIC10 induces a sustained up regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal regulated kinase (ERK), leading to the translocation