I-BRD9 - Bromodomain Containing Protein 9 (BRD9) Inhibitor. CAS# 1714146-59-4 156 Inhibition of proteasome deubiquitinating activity

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

68047-06-3

InChiKey: XGPBJCHFROADCK-UHFFFAOYSA-N

3(11):2099-106

3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine

I-BRD9 - Bromodomain Containing Protein 9 (BRD9) Inhibitor. CAS# 1714146-59-4 156 Inhibition of proteasome deubiquitinating activityI BRD9, CAS No. 1714146 59 4, is a potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1. 9 nM. It has >700 fold selectivity over the BET family and 200 fold over the highly homologous bromodomain containing protein 7 (BRD7). It downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi 1 cells. I BRD9 is the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain