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Formula: C22H28N4O2
It binds the BAX trigger site with an EC50 ~ 3
Crenolanib has 25-fold more affinity for PDGFRA/B compared with KIT
950762-95-5
CUDC-101 was IP or IV dosed to mice at 120 mg/kg once per day in the xenograft tumor model of Hep-G2
TMPA-AMPK Activator - CAS# 1258275-73-8 size:10mg solid Formula: C22H28N4O2TMPA, CAS No. 1258275 73 8, is a novel small molecule that binds to orphan Nuclear Receptor Nur77 with high affinity (Kd = 1. 45 0. 35 M), and interferes with the Nur77 LKB1 interaction. TMPAs binding to Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPK. TMPA treatment can effectively reduce blood glucose and alleviate insulin resistance in type II db db and high fat diet and streptozotocin induced diabetic mice