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SAR407899 also effectively inhibits THP-1 migration with an IC50 of 2
HIF-C2 provides an opportunity to delineate differences in HIF-1 and HIF-2 biology and serves as an entry point for development of HIF-2 inhibitor drugs for treating diseases
MRS-1191 with a KB value of 92 nM
CAS Number: 636-00-0
InChi: InChI=1S/C36H60O7/c1-20(2)10-9-11-21(3)22-12-16-36(8)28(22)23(38)18-26-34(6)15-14-27(33(4
(R)-Nedisertib tinib Malate SAR407899 also effectively inhibits THP-1(R) Nedisertib ((R) M3814) is a less active R enantiomer of Nedisertib, with an IC50 in the range of 7 30 nM for DNA PK. DNA PK 7 30 nM (IC50) Rac Nedisertib (Compound 135) less actively inhibits DNA PK, with an IC50 in the range of 7 30 nM. . Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1. Product information CAS Number: 1637542 32 5 Molecular Weight: 481. 91 Formula: C24H21ClFN5O3 Chemical Name: (R) {2 chloro 4 fluoro 5 [7 (morpholin 4