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Formula: C24H25Cl2N5O3
CAS Number: 864668-87-1
InChiKey: ZDXUKAKRHYTAKV-UHFFFAOYSA-N
4S)-2-(5-{6-[(2S
CAS Number: 70195-20-9
ARL 17477 dihydrochloride B2 Ligand Formula: C24H25Cl2N5O3ARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg
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