(S)-PFI-2 (hydrochloride) xypicolinic acid Haslinger C

Haslinger C

CC1(C)S[C@@H]2[C@H](NC(=O)COC3C=CC=CC=3)C(=O)N2[C@H]1C([O-])=O

Chemical Name: 1-[4-({6-amino-5-[(methoxyimino)methyl]pyrimidin-4-yl}oxy)-2-chlorophenyl]-3-ethylurea

Formula: C17H24N2O2

Brekken RA

(S)-PFI-2 (hydrochloride) xypicolinic acid Haslinger C(S) PFI 2 (hydrochloride) is the inactive enantiomer of (R) PFI 2 and may serve as a negative control. (R) PFI 2 is a cell permeable and potent SET7 9 inhibitor with IC50 value of 2 nM . Protein methyltransferases involve in the epigenetic regulation of gene transcription, silencing, chromatin structure establishment, maintenance, DNA repair, and replication. SET domain containing (lysine methyltransferase) 7 (SETD7) (SET9; SET7 9, KMT7) is a protein