LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1

Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1

neurological disease

It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor

Smiles: CC1C=C(C)C(=CC=1)N(/N=C/C1C=C(C=CC=1)OC)C(=O)C(F)(F)F

Formula: C22H22F3N3O3S2

LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1LDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal