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triggering rapid accumulation of polyubiquitinated proteins
Formula: C17H14Cl2F2N4OS
Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors
These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML
CAS Number: 867017-68-3
(R)-(+)-Etomoxir Sodium Salt rtine Maleate triggering rapid accumulation of polyubiquitinatedEtomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.