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and SLIGRL-NH2 is a PAR-2-activating peptide
InChiKey: ZIIAJIWLQUVGHB-UHFFFAOYSA-N
and metabolic stability in human and mouse liver microsomes
Molecular Weight: 2334
InChi: InChI=1S/C45H54F2N4O8
BGB-283 ide Rb3 and SLIGRL-NH2 is a PAR-2-activatingBGB 283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. BGB 283 potently inhibits BRafV600E activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harboring BRafV600E and EGFR mutation amplification. In BRafV600E colorectal cancer cell lines, BGB 283 effectively inhibits