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45)5)65-42-38(35(56)33(54)27(17-49)64-42)66-41-36(57)31(52)24(51)19-61-41/h22-42
treated for 72 h) inhibits AML2 cells and HL-60 cells with IC50s of 4
PMCID: PMC4382461
IC50 value: 46 nM (EC50) Target: hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described
5-b]pyrazin-6-yl)-1H-pyrazol-1-yl]ethan-1-ol
XY018 Catalog No.:M23806-C 45)5)65-42-38(35(56)33(54)27(17-49)64-42)66-41-36(57)31(52)24(51)19-61-41/h22-42XY018 is a potent ROR selective antagonist. XY018 inhibits ROR constitutive activity in 293T cells with high potency (EC50, 190 nM). XY018 binds to the ROR hydrophobic ligand binding domain (LBD). Product information CAS Number: 1873358 87 2 Molecular Weight: 516. 37 Formula: C23H15F7N2O4 Chemical Name: N [2' fluoro 4' (1,1,1,3,3,3 hexafluoro 2 hydroxypropan 2 yl) [1,1' biphenyl] 4 yl] 2 (2 nitrophenyl)acetamide Smiles: [O
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