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Smiles: CC1=NC=C(N1CCO)N(=O)=O
In neuroblastoma (NB) cell lines
24)/b19-11+
IC50 value:Target:Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines
AS601245 (0
SD-36 Catalog No.:M13867-2 Smiles: CC1=NC=C(N1CCO)N(=O)=OSD 36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD 36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD 36 exerts robust anti tumor activity, and achieves complete and long lasting tumor regression in mouse tumor models. SD 36 is composed of the STAT3 inhibitor SI 109, a linker, and an analog of
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