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CHIR-124 abrogates the SN-38-induced S and G2-M checkpoints and potentiates apoptosis in MDA-MD-435 breast cancer cells
is an orally bioavailable estradiol metabolite with potential antineoplastic activity
Smiles: C(CN1CCCC1)OC1=NC2=CC=CN=C2N=C1C#CC1C=CC=CC=1
InChi: InChI=1S/C17H13Br2N5OS
7)30(37)42/h17
D-64131 Catalog No.:M10022-2 CHIR-124 abrogates the SN-38-induced SD 64131 is a potent and selective tubulin inhibitor. D 64131 inhibits tumor cell proliferation in vitro (IC50 = 74 nM). In xenograft experiments with the human amelanoic melanoma MEXF 989, D 64131 was highly active with treatment resulting in a growth delay of 23. 4 days at 400 mg kg. Product information CAS Number: 74588 78 6 Molecular Weight: 251. 28 Formula: C16H13NO2 Chemical Name: 2 benzoyl 5 methoxy 1H indole Smiles:
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