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It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1
InChiKey: NWUDANMVYLBFML-UHFFFAOYSA-N
Human Endogenous Metabolite
VX-710 has been shown to restore sensitivity in a range of multidrug-resistant cells
InChiKey: QKDDJDBFONZGBW-UHFFFAOYSA-N
MG-277 164015 It Has only a trivialMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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